the Soy Story
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Soy & Women's Health

References for Soy & Women's Health:

  1. Setchell KDR, Cassidy A, Dietary isoflavones: biological effects and relevance to human health, J Nutr 1999;129:758S-767S.
  2. Knight DC, Lyons Wall P, Eden JA, A review of phytoestrogens and their effects in relation to menopausal symptoms, Aust J Nutr & Dietetics 1996;53:5-11.
  3. Murkies AL, Lombard C, Strauss BJG, et al., Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat, Maturitas 1995;21:189-195.
  4. Brzezinski A, Adlercreutz H, Shaoul R, et al., Short-term Effects of Phytoestrogen-rich Diet on Post-menopausal Women, Menopause 1997;4:89-94.
  5. Albertazzi P, Pansini F, Bonaccorsi G, et al., The effect of dietary soy supplementation on hot flashes, Obstet Gynecol 1998;91:6-11.
  6. Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med. 2007 May 28;167(10):1060-7.
  7. Washburn S, Burke GL, Morgan T, et al., Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women, Menopause 1999;6:7-13.
  8. Dalais FS, Rice GE, Wahlqvist ML, et al., Effects of dietary phytoestrogens in postmenopausal women, Climacteric 1998;1:124-129.
  9. Van Patten CL, Olivotto IA, Chambers GK, Gelmon KA, Hislop TG, Templeton E, Wattie A, Prior JC. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol. 2002 Mar 15;20(6):1449-55.
  10. Burke GL, Legault C, Anthony M, Bland DR, Morgan TM, Naughton MJ, Leggett K, Washburn SA, Vitolins MZ. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause. 2003 Mar-Apr;10(2):147-53.
  11. Nikander E, Kilkkinen A, Mets?-Heikkil? M, Adlercreutz H, Pietinen P, Tiitinen A, Ylikorkala O. A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients. Obstet Gynecol. 2003 Jun;101(6):1213-20.
  12. National Institute of Health. State-of-the-Science Conference statement: management of menopause-related symptoms. Ann Intern Med 2005;142:1003-13.
  13. North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause. 2004 Jan-Feb;11(1):11-33.
  14. Messina M, Hughes C. Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food. 2003 Spring;6(1):1-11.
  15. Heart, Stroke and Vascular Diseases Australian Facts, 1999, Australian Institute of Health and Welfare and National Heart Foundation of Australia.
  16. National Heart Foundation of New Zealand, Heart Facts, September 1997.
  17. Cassidy A, Bingham S, Setchell KDR, Biological effects of a isoflavones in young women: importance of the chemical composition of soyabean products, Br J Nutr 1995;74:587-601.
  18. Zhang X, Shu XO, Li H, Yang G, Li Q, Gao YT, Zheng W. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med. 2005 Sep 12;165(16):1890-5.
  19. Scheiber MD, Liu JH, Subbiah MT, Rebar RW, Setchell KD. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause. 2001 Sep-Oct;8(5):384-92.
  20. Ma DF, Qin LQ, Wang PY, Katoh R. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2008 Feb;62(2):155-61. Epub 2007 Mar 28.
  21. Potter SM, Baum J, Teng H, et al., Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women, Am J Clin Nutr 1998;68(suppl):1375S-9S.
  22. Ma DF, Qin LQ, Wang PY, Katoh R. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clin Nutr. 2008 Feb;27(1):57-64. Epub 2007 Dec 11.
  23. Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F; PHYTOS Investigators. Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr. 2008 Mar;87(3):761-70.
  24. Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y. Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial. Menopause. 2007 Sep-Oct;14(5):866-74.
  25. Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr. 2002 Dec;132(12):3577-84.
  26. Stephenson J. FDA orders estrogen safety warnings: agency offers guidance for HRT use. JAMA. 2003 Feb 5;289(5):537-8.
  27. U.S. Preventive Services Task Force. Postmenopausal hormone replacement therapy for primary prevention of chronic conditions: recommendations and rationale. Ann Intern Med. 2002 Nov 19;137(10):834-9.